Reaction Details |
| Report a problem with these data |
Target | Nucleotide-binding oligomerization domain-containing protein 1 |
---|
Ligand | BDBM50239692 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1666697 (CHEMBL4016493) |
---|
IC50 | 1110±n/a nM |
---|
Citation | Wang, S; Yang, J; Li, X; Liu, Z; Wu, Y; Si, G; Tao, Y; Zhao, N; Hu, X; Ma, Y; Liu, G Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo. J Med Chem60:5162-5192 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Nucleotide-binding oligomerization domain-containing protein 1 |
---|
Name: | Nucleotide-binding oligomerization domain-containing protein 1 |
Synonyms: | CARD4 | NOD1 | NOD1_HUMAN | nucleotide-binding oligomerization domain containing 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 107699.03 |
Organism: | Homo sapiens (Human) |
Description: | gi_5174617 |
Residue: | 953 |
Sequence: | MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCA
CPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVV
VNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSL
ACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFS
CFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPD
SSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAY
ARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMT
LTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQ
EEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQEL
LRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAK
QKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIY
ETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGV
RELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL
DECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP
SLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKH
LWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF
|
|
|
BDBM50239692 |
---|
n/a |
---|
Name | BDBM50239692 |
Synonyms: | CHEMBL4091371 |
Type | Small organic molecule |
Emp. Form. | C33H39N5O6 |
Mol. Mass. | 601.6927 |
SMILES | CN(C)c1cccc(Oc2cc3c(NC(=O)[C@@H](CCC(=O)NC(C)(C)C)NC3=O)cc2NC(=O)COCc2ccccc2)c1 |r| |
Structure |
|