| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-I |
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| Ligand | BDBM50239863 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1667493 (CHEMBL4017289) |
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| IC50 | >100000±n/a nM |
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| Citation |  Iwatani-Yoshihara, M; Ito, M; Klein, MG; Yamamoto, T; Yonemori, K; Tanaka, T; Miwa, M; Morishita, D; Endo, S; Tjhen, R; Qin, L; Nakanishi, A; Maezaki, H; Kawamoto, T Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J Med Chem60:5759-5771 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic initiation factor 4A-I |
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| Name: | Eukaryotic initiation factor 4A-I |
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| Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46146.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_864983 |
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| Residue: | 406 |
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| Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
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| BDBM50239863 |
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| n/a |
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| Name | BDBM50239863 |
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| Synonyms: | CHEMBL4087449 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25FN4O3 |
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| Mol. Mass. | 496.5322 |
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| SMILES | Cc1cc2CCC(Oc2cc1N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O)c1ncccc1F |
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| Structure | 
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