| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Tec |
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| Ligand | BDBM50240575 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1668451 (CHEMBL4018339) |
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| IC50 | >10000±n/a nM |
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| Citation |  Wang, Y; Chen, Z; Dai, M; Sun, P; Wang, C; Gao, Y; Zhao, H; Zeng, W; Shen, L; Mao, W; Wang, T; Hu, G; Li, J; Chen, S; Long, C; Chen, X; Liu, J; Zhang, Y Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping. Bioorg Med Chem Lett27:2420-2423 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Tec |
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| Name: | Tyrosine-protein kinase Tec |
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| Synonyms: | PSCTK4 | TEC | TEC_HUMAN | Tyrosine-protein kinase TEC (TEC) |
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| Type: | Protein |
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| Mol. Mass.: | 73597.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 631 |
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| Sequence: | MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK
CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY
HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS
EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN
NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY
HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY
EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL
THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL
ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS
RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR
CWQEKPEGRPSFEDLLRTIDELVECEETFGR
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| BDBM50240575 |
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| n/a |
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| Name | BDBM50240575 |
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| Synonyms: | CHEMBL4089245 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22F2N4O4 |
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| Mol. Mass. | 456.442 |
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| SMILES | COc1cc(OC)c(F)c(COc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2)c1F |
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| Structure | 
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