| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 4 |
|---|
| Ligand | BDBM50233461 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1668422 (CHEMBL4018310) |
|---|
| IC50 | 49±n/a nM |
|---|
| Citation |  Wang, Y; Chen, Z; Dai, M; Sun, P; Wang, C; Gao, Y; Zhao, H; Zeng, W; Shen, L; Mao, W; Wang, T; Hu, G; Li, J; Chen, S; Long, C; Chen, X; Liu, J; Zhang, Y Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping. Bioorg Med Chem Lett27:2420-2423 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fibroblast growth factor receptor 4 |
|---|
| Name: | Fibroblast growth factor receptor 4 |
|---|
| Synonyms: | CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 87957.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22455 |
|---|
| Residue: | 802 |
|---|
| Sequence: | MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA
AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
VFSHDPLPLGSSSFPFGSGVQT
|
|
|
|---|
| BDBM50233461 |
|---|
| n/a |
|---|
| Name | BDBM50233461 |
|---|
| Synonyms: | CHEMBL4068896 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H22Cl2N4O3 |
|---|
| Mol. Mass. | 509.384 |
|---|
| SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
