| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50240694 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1668607 (CHEMBL4018495) |
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| Ki | 16±n/a nM |
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| Citation |  Davoren, JE; Garnsey, M; Pettersen, B; Brodney, MA; Edgerton, JR; Fortin, JP; Grimwood, S; Harris, AR; Jenkinson, S; Kenakin, T; Lazzaro, JT; Lee, CW; Lotarski, SM; Nottebaum, L; O'Neil, SV; Popiolek, M; Ramsey, S; Steyn, SJ; Thorn, CA; Zhang, L; Webb, D Design and Synthesis of?- and?-Lactam M J Med Chem60:6649-6663 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
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| Type: | Protein |
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| Mol. Mass.: | 51442.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11229 |
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| Residue: | 460 |
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| Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50240694 |
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| n/a |
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| Name | BDBM50240694 |
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| Synonyms: | CHEMBL4067722 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24N2O4 |
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| Mol. Mass. | 404.4584 |
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| SMILES | Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cocn1 |r| |
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| Structure | 
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