Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50240958 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1669358 (CHEMBL4019246) |
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Ki | 1432±n/a nM |
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Citation | Erli, F; Guerrieri, E; Ben Haddou, T; Lantero, A; Mairegger, M; Schmidhammer, H; Spetea, M Highly Potent and Selective New Diphenethylamines Interacting with the?-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships. J Med Chem60:7579-7590 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50240958 |
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n/a |
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Name | BDBM50240958 |
Synonyms: | CHEMBL4065350 |
Type | Small organic molecule |
Emp. Form. | C23H32ClNO2 |
Mol. Mass. | 389.959 |
SMILES | Cl.Oc1cccc(CCN(CCc2cccc(O)c2)CC2CCCCC2)c1 |
Structure |
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