| Reaction Details |
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 | Report a problem with these data |
| Target | RAS guanyl-releasing protein 1 |
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| Ligand | BDBM50244449 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1670921 (CHEMBL4020950) |
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| Ki | 0.580000±n/a nM |
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| Citation |  Elhalem, E; Donadío, LG; Zhou, X; Lewin, NE; Garcia, LC; Lai, CC; Kelley, JA; Peach, ML; Blumberg, PM; Comin, MJ Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKC?, PKC?, and RasGRP. Bioorg Med Chem25:2971-2980 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAS guanyl-releasing protein 1 |
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| Name: | RAS guanyl-releasing protein 1 |
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| Synonyms: | CalDAG-GEFII | Calcium and DAG-regulated guanine nucleotide exchange factor II | GRP1_HUMAN | RASGRP | RASGRP1 | Ras guanyl-releasing protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 90418.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_102739 |
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| Residue: | 797 |
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| Sequence: | MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA
SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPG
LCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWS
RKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKE
NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGG
LCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLK
DLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY
YTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFK
NYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGF
PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA
PTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKI
SLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVR
KRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQ
LEKSNHVLAQMEQGDCS
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| BDBM50244449 |
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| n/a |
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| Name | BDBM50244449 |
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| Synonyms: | (E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxo-tetrahydrofuran-2-yl)methyl 2-propylpentanoate | CHEMBL519741 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31NO5 |
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| Mol. Mass. | 413.5066 |
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| SMILES | CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1 |
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| Structure | 
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