| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50243038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1672494 |
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| IC50 | 4710±n/a nM |
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| Citation |  Tong, L; Kim, SH; Rosner, K; Yu, W; Shankar, BB; Chen, L; Li, D; Dai, C; Girijavallabhan, V; Popovici-Muller, J; Yang, L; Zhou, G; Kosinski, A; Siddiqui, MA; Shih, NY; Guo, Z; Orth, P; Chen, S; Lundell, D; Niu, X; Umland, S; Kozlowski, JA Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors. Bioorg Med Chem Lett27:3037-3042 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50243038 |
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| n/a |
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| Name | BDBM50243038 |
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| Synonyms: | CHEMBL4092752 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N4O5 |
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| Mol. Mass. | 392.3648 |
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| SMILES | COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3cc4cnccc4o3)C(=O)c2c1 |r| |
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| Structure | 
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