| Reaction Details |
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 | Report a problem with these data |
| Target | Chitotriosidase-1 |
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| Ligand | BDBM50243745 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1672916 (CHEMBL4022945) |
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| Ki | 312±n/a nM |
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| Citation |  Mazur, M; Olczak, J; Olejniczak, S; Koralewski, R; Czestkowski, W; Jedrzejczak, A; Golab, J; Dzwonek, K; Dymek, B; Sklepkiewicz, PL; Zagozdzon, A; Noonan, T; Mahboubi, K; Conway, B; Sheeler, R; Beckett, P; Hungerford, WM; Podjarny, A; Mitschler, A; Cousido-Siah, A; Fadel, F; Golebiowski, A Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J Med Chem61:695-710 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chitotriosidase-1 |
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| Name: | Chitotriosidase-1 |
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| Synonyms: | CHIT1 | CHIT1_HUMAN | Chitinase 1 | Chitinase-1 | Chitotriosidase | Chitotriosidase-1 | Chitotriosidase-1 (CHIT1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51682.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13231 |
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| Residue: | 466 |
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| Sequence: | MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAG
MTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFV
NSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLL
SAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAAS
LNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGM
LAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWAL
DLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFC
QGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
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| BDBM50243745 |
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| n/a |
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| Name | BDBM50243745 |
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| Synonyms: | CHEMBL4076989 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H29ClN6 |
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| Mol. Mass. | 376.927 |
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| SMILES | CC(C)CN(CCc1ccc(Cl)cc1)C1CCN(CC1)c1nc(N)n[nH]1 |
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| Structure | 
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