Reaction Details |
| Report a problem with these data |
Target | Acyl-CoA (8-3)-desaturase |
---|
Ligand | BDBM50246047 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1676416 (CHEMBL4026559) |
---|
IC50 | 47±n/a nM |
---|
Citation | Fujimoto, J; Okamoto, R; Noguchi, N; Hara, R; Masada, S; Kawamoto, T; Nagase, H; Tamura, YO; Imanishi, M; Takagahara, S; Kubo, K; Tohyama, K; Iida, K; Andou, T; Miyahisa, I; Matsui, J; Hayashi, R; Maekawa, T; Matsunaga, N Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available?-5 Desaturase (D5D) Inhibitors. J Med Chem60:8963-8981 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Acyl-CoA (8-3)-desaturase |
---|
Name: | Acyl-CoA (8-3)-desaturase |
Synonyms: | FADS1_RAT | Fads1 | Fatty acid desaturase 1 |
Type: | PROTEIN |
Mol. Mass.: | 52505.96 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_852948 |
Residue: | 447 |
Sequence: | MAPDPVQTPDPASAQLRQMRYFTWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSR
VISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPSFEPTKNKALTDEFRELRA
TVERMGLMKANHLFFLFYLLHILLLDVAAWLTLWIFGTSLVPFTLCAVLLSTVQAQAGWL
QHDFGHLSVFSTSTWNHLVHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPL
FFALGKVLSVELGKEKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWVDLA
WMLSFYVRVFFTYMPLLGLKGLLCLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNVDWVS
TQLQATCNVHQSAFNNWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKYGIKYESK
PLLTAFADIVYSLKESGQLWLDAYLHQ
|
|
|
BDBM50246047 |
---|
n/a |
---|
Name | BDBM50246047 |
Synonyms: | CHEMBL4097127 |
Type | Small organic molecule |
Emp. Form. | C20H21FN2O |
Mol. Mass. | 324.3919 |
SMILES | CCn1cc(C(=O)N(C)C(C)c2ccc(F)cc2)c2ccccc12 |
Structure |
|