| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA (8-3)-desaturase |
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| Ligand | BDBM50246049 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1676416 (CHEMBL4026559) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Fujimoto, J; Okamoto, R; Noguchi, N; Hara, R; Masada, S; Kawamoto, T; Nagase, H; Tamura, YO; Imanishi, M; Takagahara, S; Kubo, K; Tohyama, K; Iida, K; Andou, T; Miyahisa, I; Matsui, J; Hayashi, R; Maekawa, T; Matsunaga, N Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available?-5 Desaturase (D5D) Inhibitors. J Med Chem60:8963-8981 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA (8-3)-desaturase |
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| Name: | Acyl-CoA (8-3)-desaturase |
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| Synonyms: | FADS1_RAT | Fads1 | Fatty acid desaturase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52505.96 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_852948 |
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| Residue: | 447 |
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| Sequence: | MAPDPVQTPDPASAQLRQMRYFTWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSR
VISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPSFEPTKNKALTDEFRELRA
TVERMGLMKANHLFFLFYLLHILLLDVAAWLTLWIFGTSLVPFTLCAVLLSTVQAQAGWL
QHDFGHLSVFSTSTWNHLVHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPL
FFALGKVLSVELGKEKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWVDLA
WMLSFYVRVFFTYMPLLGLKGLLCLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNVDWVS
TQLQATCNVHQSAFNNWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKYGIKYESK
PLLTAFADIVYSLKESGQLWLDAYLHQ
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| BDBM50246049 |
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| n/a |
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| Name | BDBM50246049 |
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| Synonyms: | CHEMBL4102458 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12F2N2O2 |
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| Mol. Mass. | 314.2862 |
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| SMILES | C[C@H]1[C@@H](OC(=O)N1c1cc(F)cc(c1)C#N)c1ccc(F)cc1 |r| |
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| Structure | 
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