Reaction Details |
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Target | Cyclin-C/Cyclin-dependent kinase 19 |
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Ligand | BDBM50248608 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1679275 (CHEMBL4029552) |
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IC50 | 19±n/a nM |
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Citation | Ono, K; Banno, H; Okaniwa, M; Hirayama, T; Iwamura, N; Hikichi, Y; Murai, S; Hasegawa, M; Hasegawa, Y; Yonemori, K; Hata, A; Aoyama, K; Cary, DR Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivatives. Bioorg Med Chem25:2336-2350 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-C/Cyclin-dependent kinase 19 |
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Name: | Cyclin-C/Cyclin-dependent kinase 19 |
Synonyms: | CDK19/Cyclin C |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 19 |
Synonyms: | CDC2-related protein kinase 6 | CDC2L6 | CDK11 | CDK19 | CDK19_HUMAN | Cell division cycle 2-like protein kinase 6 | Cell division protein kinase 19 | Cyclin-dependent kinase 11 | Death-preventing kinase | KIAA1028 |
Type: | Serine/Threonine protein kinase |
Mol. Mass.: | 56816.68 |
Organism: | Homo sapiens (Human) |
Description: | Q9BWU1 |
Residue: | 502 |
Sequence: | MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS
MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP
MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH
KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN
EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG
AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST
LGYSSSSQQSSQYHPSHQAHRY
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Component 2 |
Name: | Cyclin-C |
Synonyms: | CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11 |
Type: | PROTEIN |
Mol. Mass.: | 33244.88 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107900 |
Residue: | 283 |
Sequence: | MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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BDBM50248608 |
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n/a |
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Name | BDBM50248608 |
Synonyms: | CHEMBL4063358 |
Type | Small organic molecule |
Emp. Form. | C12H13N3OS2 |
Mol. Mass. | 279.381 |
SMILES | CSc1sc(C(N)=O)c2CCc3cnn(C)c3-c12 |
Structure |
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