| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 19 |
|---|
| Ligand | BDBM50248614 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1679219 (CHEMBL4029496) |
|---|
| Kd | 25±n/a nM |
|---|
| Citation |  Ono, K; Banno, H; Okaniwa, M; Hirayama, T; Iwamura, N; Hikichi, Y; Murai, S; Hasegawa, M; Hasegawa, Y; Yonemori, K; Hata, A; Aoyama, K; Cary, DR Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivatives. Bioorg Med Chem25:2336-2350 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 19 |
|---|
| Name: | Cyclin-dependent kinase 19 |
|---|
| Synonyms: | CDC2-related protein kinase 6 | CDC2L6 | CDK11 | CDK19 | CDK19_HUMAN | Cell division cycle 2-like protein kinase 6 | Cell division protein kinase 19 | Cyclin-dependent kinase 11 | Death-preventing kinase | KIAA1028 |
|---|
| Type: | Serine/Threonine protein kinase |
|---|
| Mol. Mass.: | 56816.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BWU1 |
|---|
| Residue: | 502 |
|---|
| Sequence: | MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS
MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP
MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH
KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN
EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG
AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST
LGYSSSSQQSSQYHPSHQAHRY
|
|
|
|---|
| BDBM50248614 |
|---|
| n/a |
|---|
| Name | BDBM50248614 |
|---|
| Synonyms: | CHEMBL4066819 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18N4O4S2 |
|---|
| Mol. Mass. | 430.501 |
|---|
| SMILES | COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 |
|---|
| Structure | 
|
|---|
Search and Browse
