Reaction Details |
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Target | Cytochrome P450 11B2, mitochondrial |
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Ligand | BDBM50249045 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1679698 (CHEMBL4029975) |
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IC50 | 14±n/a nM |
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Citation | Hoyt, SB; Taylor, J; London, C; Ali, A; Ujjainwalla, F; Tata, J; Struthers, M; Cully, D; Wisniewski, T; Ren, N; Bopp, C; Sok, A; Verras, A; McMasters, D; Chen, Q; Tung, E; Tang, W; Salituro, G; Clemas, J; Zhou, G; MacNeil, D; Duffy, R; Xiong, Y Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension. Bioorg Med Chem Lett27:2384-2388 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B2, mitochondrial |
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Name: | Cytochrome P450 11B2, mitochondrial |
Synonyms: | Aldosterone synthase | C11B2_RAT | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P450-Aldo-1 | Steroid 11-beta-hydroxylase |
Type: | PROTEIN |
Mol. Mass.: | 58260.64 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_224979 |
Residue: | 510 |
Sequence: | MGACDNDFIELHSRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIPQYSRNKWL
KMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRR
MHLEPWVAHRELRGLRRGVFLLNGAEWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLE
ALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSLKFIHALHSM
FKSTTQLLFLPRSLTRWTSTQVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIV
AALITQGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEAS
IAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYLYSM
GRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQV
ETLRQEDVQMAYRFVLMPSSSPVLTFRPIS
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BDBM50249045 |
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n/a |
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Name | BDBM50249045 |
Synonyms: | CHEMBL4098297 |
Type | Small organic molecule |
Emp. Form. | C16H14F3N3O |
Mol. Mass. | 321.2971 |
SMILES | Cc1nn(-c2cncc(c2)[C@](C)(O)C(F)(F)F)c2ccccc12 |r| |
Structure |
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