| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50250858 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1682364 (CHEMBL4032641) |
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| IC50 | 3.0±n/a nM |
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| Citation |  Butler, CR; Beck, EM; Harris, A; Huang, Z; McAllister, LA; Am Ende, CW; Fennell, K; Foley, TL; Fonseca, K; Hawrylik, SJ; Johnson, DS; Knafels, JD; Mente, S; Noell, GS; Pandit, J; Phillips, TB; Piro, JR; Rogers, BN; Samad, TA; Wang, J; Wan, S; Brodney, MA Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase. J Med Chem60:9860-9873 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM50250858 |
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| n/a |
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| Name | BDBM50250858 |
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| Synonyms: | CHEMBL4078417 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13F6N3O2 |
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| Mol. Mass. | 417.3051 |
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| SMILES | FC(F)(F)C(OC(=O)N1CC(C1)c1ccn(n1)-c1ccc(cc1)C#C)C(F)(F)F |
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| Structure | 
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