| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM254381 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1683149 |
|---|
| IC50 | 10.0±n/a nM |
|---|
| Citation |  Chrovian, CC; Soyode-Johnson, A; Peterson, AA; Gelin, CF; Deng, X; Dvorak, CA; Carruthers, NI; Lord, B; Fraser, I; Aluisio, L; Coe, KJ; Scott, B; Koudriakova, T; Schoetens, F; Sepassi, K; Gallacher, DJ; Bhattacharya, A; Letavic, MA A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate. J Med Chem61:207-223 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68403.50 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q64663 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
|
|
|
|---|
| BDBM254381 |
|---|
| n/a |
|---|
| Name | BDBM254381 |
|---|
| Synonyms: | US10112937, Example 288 | US10150765, Example 288 | US10703749, Example 288 | US9464084, 288 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H16ClF3N4O |
|---|
| Mol. Mass. | 420.815 |
|---|
| SMILES | C[C@H]1Cc2c(CN1C(=O)c1cccc(c1Cl)C(F)(F)F)nnn2-c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
