| Reaction Details |
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 | Report a problem with these data |
| Target | Cell division cycle 7-related protein kinase |
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| Ligand | BDBM50253753 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1685781 |
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| IC50 | 350±n/a nM |
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| Citation |  Kurasawa, O; Homma, M; Oguro, Y; Miyazaki, T; Mori, K; Uchiyama, N; Iwai, K; Ohashi, A; Hara, H; Yoshida, S; Cho, N 2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase. Bioorg Med Chem25:3658-3670 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cell division cycle 7-related protein kinase |
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| Name: | Cell division cycle 7-related protein kinase |
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| Synonyms: | CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7 |
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| Type: | Protein |
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| Mol. Mass.: | 63908.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00311 |
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| Residue: | 574 |
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| Sequence: | MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI
EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV
KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP
SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG
PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH
ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC
SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD
LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ
GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD
EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
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| BDBM50253753 |
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| n/a |
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| Name | BDBM50253753 |
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| Synonyms: | CHEMBL4062209 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H17Cl2N5OS |
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| Mol. Mass. | 362.278 |
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| SMILES | Cl.Cl.CN(C)Cc1nc2cc(sc2c(=O)[nH]1)-c1c[nH]nc1C |
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| Structure | 
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