| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50008286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54603 |
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| Ki | 0.017000±n/a nM |
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| Citation |  DeGraw, JI; Christie, PH; Colwell, WT; Sirotnak, FM Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin. J Med Chem35:320-4 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
|
|
|
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| BDBM50008286 |
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| n/a |
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| Name | BDBM50008286 |
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| Synonyms: | 2-[4-(1,3-Diamino-7,8,9,10-tetrahydro-pyrimido[4,5-c]isoquinolin-8-yl)-benzoylamino]-pentanedioic acid | CHEMBL109229 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N6O5 |
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| Mol. Mass. | 464.4739 |
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| SMILES | Nc1nc(N)c2c3CCC(Cc3cnc2n1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O |
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| Structure | 
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