Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50008285 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_54603 |
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Ki | 0.013000±n/a nM |
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Citation | DeGraw, JI; Christie, PH; Colwell, WT; Sirotnak, FM Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin. J Med Chem35:320-4 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_MOUSE | Dhfr |
Type: | Enzyme |
Mol. Mass.: | 21608.82 |
Organism: | Mus musculus (Mouse) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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BDBM50008285 |
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n/a |
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Name | BDBM50008285 |
Synonyms: | 2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid | CHEMBL113799 |
Type | Small organic molecule |
Emp. Form. | C23H26N6O5 |
Mol. Mass. | 466.4897 |
SMILES | CCC(Cc1cnc2nc(N)nc(N)c2c1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O |
Structure |
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