| Reaction Details |
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 | Report a problem with these data |
| Target | Inward rectifier potassium channel 2 |
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| Ligand | BDBM50258216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1690315 |
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| IC50 | >30000±n/a nM |
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| Citation |  Martinez Botella, G; Salituro, FG; Harrison, BL; Beresis, RT; Bai, Z; Blanco, MJ; Belfort, GM; Dai, J; Loya, CM; Ackley, MA; Althaus, AL; Grossman, SJ; Hoffmann, E; Doherty, JJ; Robichaud, AJ Neuroactive Steroids. 2. 3?-Hydroxy-3?-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5?-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (?-Aminobutyric Acid) J Med Chem60:7810-7819 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inward rectifier potassium channel 2 |
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| Name: | Inward rectifier potassium channel 2 |
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| Synonyms: | Cardiac inward rectifier potassium channel | IRK-1 | IRK1 | Inward rectifier K(+) channel Kir2.1 | KCNJ2 | KCNJ2_HUMAN | Potassium channel, inwardly rectifying subfamily J member 2 | hIRK1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48281.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1515520 |
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| Residue: | 427 |
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| Sequence: | MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFIN
VGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGK
ACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVM
AKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEG
EYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEG
MVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARD
LAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRP
LRRESEI
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| BDBM50258216 |
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| n/a |
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| Name | BDBM50258216 |
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| Synonyms: | CHEMBL4105630 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H35N3O2 |
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| Mol. Mass. | 409.5643 |
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| SMILES | [H][C@@]12CC[C@H](C(=O)Cn3cc(cn3)C#N)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@](C)(O)CC[C@]12[H] |r| |
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| Structure | 
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