Reaction Details |
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Target | Falcipain 2 |
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Ligand | BDBM50157741 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1690554 |
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IC50 | 250±n/a nM |
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Citation | Previti, S; Ettari, R; Cosconati, S; Amendola, G; Chouchene, K; Wagner, A; Hellmich, UA; Ulrich, K; Krauth-Siegel, RL; Wich, PR; Schmid, I; Schirmeister, T; Gut, J; Rosenthal, PJ; Grasso, S; Zappalą, M Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs). J Med Chem60:6911-6923 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Falcipain 2 |
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Name: | Falcipain 2 |
Synonyms: | Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2 |
Type: | Enzyme |
Mol. Mass.: | 55912.60 |
Organism: | Plasmodium falciparum |
Description: | Recombinant falcipain-2. |
Residue: | 484 |
Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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BDBM50157741 |
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n/a |
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Name | BDBM50157741 |
Synonyms: | CHEMBL374508 | E-64 | E64 |
Type | Small organic molecule |
Emp. Form. | C15H27N5O5 |
Mol. Mass. | 357.4054 |
SMILES | [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H]-1-[#8]-[#6@@H]-1-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r| |
Structure |
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