| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 1A |
|---|
| Ligand | BDBM50259695 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1691612 |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Wang, S; Zhao, LJ; Zheng, YC; Shen, DD; Miao, EF; Qiao, XP; Zhao, LJ; Liu, Y; Huang, R; Yu, B; Liu, HM Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors. Eur J Med Chem125:940-951 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysine-specific histone demethylase 1A |
|---|
| Name: | Lysine-specific histone demethylase 1A |
|---|
| Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 92901.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60341 |
|---|
| Residue: | 852 |
|---|
| Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
|
|
|
|---|
| BDBM50259695 |
|---|
| n/a |
|---|
| Name | BDBM50259695 |
|---|
| Synonyms: | CHEMBL4101488 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H16BrN7S |
|---|
| Mol. Mass. | 466.357 |
|---|
| SMILES | Cc1cc(Nc2ccc(Br)cc2)n2nc(SCc3nc4ccccc4[nH]3)nc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
