| Reaction Details |
|---|
 | Report a problem with these data |
| Target | G-protein coupled receptor 35 |
|---|
| Ligand | BDBM50259839 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1691965 (CHEMBL4042614) |
|---|
| IC50 | 8.6±n/a nM |
|---|
| Citation |  Wei, L; Wang, J; Zhang, X; Wang, P; Zhao, Y; Li, J; Hou, T; Qu, L; Shi, L; Liang, X; Fang, Y Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists. J Med Chem60:362-372 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| G-protein coupled receptor 35 |
|---|
| Name: | G-protein coupled receptor 35 |
|---|
| Synonyms: | G protein-coupled receptor 35 | GPR35 | GPR35_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 34085.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_33695097 |
|---|
| Residue: | 309 |
|---|
| Sequence: | MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMT
NLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRH
PLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGF
YLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVR
LAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKS
QDSLCVTLA
|
|
|
|---|
| BDBM50259839 |
|---|
| n/a |
|---|
| Name | BDBM50259839 |
|---|
| Synonyms: | CHEMBL4100677 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H4BrN5O5 |
|---|
| Mol. Mass. | 354.073 |
|---|
| SMILES | Oc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
