| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 4 |
|---|
| Ligand | BDBM50260185 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1692890 |
|---|
| IC50 | 69±n/a nM |
|---|
| Citation |  Li, X; Guise, CP; Taghipouran, R; Yosaatmadja, Y; Ashoorzadeh, A; Paik, WK; Squire, CJ; Jiang, S; Luo, J; Xu, Y; Tu, ZC; Lu, X; Ren, X; Patterson, AV; Smaill, JB; Ding, K 2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors. Eur J Med Chem135:531-543 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fibroblast growth factor receptor 4 |
|---|
| Name: | Fibroblast growth factor receptor 4 |
|---|
| Synonyms: | CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 87957.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22455 |
|---|
| Residue: | 802 |
|---|
| Sequence: | MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA
AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
VFSHDPLPLGSSSFPFGSGVQT
|
|
|
|---|
| BDBM50260185 |
|---|
| n/a |
|---|
| Name | BDBM50260185 |
|---|
| Synonyms: | CHEMBL4096041 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H35Cl2N7O4 |
|---|
| Mol. Mass. | 640.56 |
|---|
| SMILES | COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
