Reaction Details |
| Report a problem with these data |
Target | Aldo-keto reductase family 1 member B1 |
---|
Ligand | BDBM50009790 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_157078 |
---|
IC50 | 140±n/a nM |
---|
Citation | Mylari, BL; Larson, ER; Beyer, TA; Zembrowski, WJ; Aldinger, CE; Dee, MF; Siegel, TW; Singleton, DH Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners. J Med Chem34:108-22 (1991) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Aldo-keto reductase family 1 member B1 |
---|
Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR) |
Type: | Protein |
Mol. Mass.: | 35855.50 |
Organism: | Homo sapiens (Human) |
Description: | P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0 |
Residue: | 316 |
Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
|
|
|
BDBM50009790 |
---|
n/a |
---|
Name | BDBM50009790 |
Synonyms: | 5'-fluoro-1'-(4-fluorobenzyl)spiro[tetrahydro-1H-imidazole-4,3'-(2',3'-dihydro-1'H-indole)]-2,5-dione | CHEMBL281620 |
Type | Small organic molecule |
Emp. Form. | C17H13F2N3O2 |
Mol. Mass. | 329.3008 |
SMILES | Fc1ccc(CN2CC3(NC(=O)NC3=O)c3cc(F)ccc23)cc1 |
Structure |
|