| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cysteine protease |
|---|
| Ligand | BDBM50263570 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1698165 |
|---|
| Ki | 1.000000±n/a nM |
|---|
| Citation |  Giroud, M; Dietzel, U; Anselm, L; Banner, D; Kuglstatter, A; Benz, J; Blanc, JB; Gaufreteau, D; Liu, H; Lin, X; Stich, A; Kuhn, B; Schuler, F; Kaiser, M; Brun, R; Schirmeister, T; Kisker, C; Diederich, F; Haap, W Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors. J Med Chem61:3350-3369 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cysteine protease |
|---|
| Name: | Cysteine protease |
|---|
| Synonyms: | Rhodesain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48425.78 |
|---|
| Organism: | Trypanosoma brucei rhodesiense |
|---|
| Description: | ChEMBL_619861 |
|---|
| Residue: | 450 |
|---|
| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
|
|
|
|---|
| BDBM50263570 |
|---|
| n/a |
|---|
| Name | BDBM50263570 |
|---|
| Synonyms: | CHEMBL4066422 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H24ClN3O4 |
|---|
| Mol. Mass. | 501.961 |
|---|
| SMILES | Clc1cc2C[C@H](NC(=O)c3cc4ccccc4cc3OC\C=C\COc1cc2)C(=O)NC1(CC1)C#N |r,t:23| |
|---|
| Structure | 
|
|---|
Search and Browse
