| Reaction Details |
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 | Report a problem with these data |
| Target | COP9 signalosome complex subunit 5 |
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| Ligand | BDBM50264420 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1698724 (CHEMBL4049706) |
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| IC50 | 4000±n/a nM |
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| Citation |  Perez, C; Li, J; Parlati, F; Rouffet, M; Ma, Y; Mackinnon, AL; Chou, TF; Deshaies, RJ; Cohen, SM Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem60:1343-1361 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| COP9 signalosome complex subunit 5 |
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| Name: | COP9 signalosome complex subunit 5 |
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| Synonyms: | COP9 signalosome complex subunit 5 (Csn5) | COPS5 | CSN5 | CSN5_HUMAN | JAB1 |
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| Type: | Protein |
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| Mol. Mass.: | 37578.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92905 |
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| Residue: | 334 |
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| Sequence: | MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISAL
ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY
IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGK
VNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLEL
LWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL
AKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
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| BDBM50264420 |
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| n/a |
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| Name | BDBM50264420 |
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| Synonyms: | CHEMBL4100384 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H26N4O2S4 |
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| Mol. Mass. | 626.834 |
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| SMILES | O=C(NCCc1cccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCCc3cccs3)cccc2c1 |
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| Structure | 
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