| Reaction Details |
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 | Report a problem with these data |
| Target | Neurotensin receptor type 2 |
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| Ligand | BDBM50342242 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1700227 (CHEMBL4051209) |
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| IC50 | 0.950000±n/a nM |
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| Citation |  Fanelli, R; Floquet, N; Besserer-Offroy, É; Delort, B; Vivancos, M; Longpré, JM; Renault, P; Martinez, J; Sarret, P; Cavelier, F Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues. J Med Chem60:3303-3313 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neurotensin receptor type 2 |
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| Name: | Neurotensin receptor type 2 |
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| Synonyms: | Levocabastine-sensitive neurotensin receptor | NT-R-2 | NTR2 | NTR2 receptor | NTR2_HUMAN | NTSR2 | Neurotensin receptor | Neurotensin receptor 2 | Neurotensin receptor type 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45404.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1281495 |
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| Residue: | 410 |
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| Sequence: | METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKA
RAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAY
ATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHEL
ETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQV
PSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLR
AIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNA
VSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
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| BDBM50342242 |
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| n/a |
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| Name | BDBM50342242 |
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| Synonyms: | (S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-6-amino-2-((S)-2,6-diaminohexanamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid | CHEMBL258221 | H-Lys-Lys-Pro-Tyr-Ile-Leu-OH |
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| Type | Small organic molecule |
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| Emp. Form. | C38H64N8O8 |
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| Mol. Mass. | 760.9636 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O |
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| Structure | 
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