| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
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| Ligand | BDBM248955 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1701139 (CHEMBL4052121) |
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| Ki | 0.008000±n/a nM |
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| Citation |  Wang, X; Kolesnikov, A; Tay, S; Chan, G; Chao, Q; Do, S; Drummond, J; Ebens, AJ; Liu, N; Ly, J; Harstad, E; Hu, H; Moffat, J; Munugalavadla, V; Murray, J; Slaga, D; Tsui, V; Volgraf, M; Wallweber, H; Chang, JH Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem60:4458-4473 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-3 |
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| Name: | Serine/threonine-protein kinase pim-3 |
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| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
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| Type: | Protein |
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| Mol. Mass.: | 35888.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86V86 |
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| Residue: | 326 |
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| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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| BDBM248955 |
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| n/a |
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| Name | BDBM248955 |
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| Synonyms: | US9434725, 186 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N8O |
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| Mol. Mass. | 416.479 |
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| SMILES | COc1ccc(nc1N1CCC[C@H](N)C1)-n1ncc2cnc(cc12)-c1cncc(C)n1 |r| |
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| Structure | 
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