| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-lysine 6-oxidase |
|---|
| Ligand | BDBM50266822 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1701351 |
|---|
| IC50 | 35000±n/a nM |
|---|
| Citation |  Rowbottom, MW; Bain, G; Calderon, I; Lasof, T; Lonergan, D; Lai, A; Huang, F; Darlington, J; Prodanovich, P; Santini, AM; King, CD; Goulet, L; Shannon, KE; Ma, GL; Nguyen, K; MacKenna, DA; Evans, JF; Hutchinson, JH Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem60:4403-4423 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-lysine 6-oxidase |
|---|
| Name: | Protein-lysine 6-oxidase |
|---|
| Synonyms: | LOX | LYOX_HUMAN | Lysyl oxidase | alpha-Glucosidase (alpha-Glu) |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 46954.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_306619 |
|---|
| Residue: | 417 |
|---|
| Sequence: | MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL
GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT
ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD
NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA
EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
|
|
|
|---|
| BDBM50266822 |
|---|
| n/a |
|---|
| Name | BDBM50266822 |
|---|
| Synonyms: | CHEMBL4079398 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18ClF4N3O3 |
|---|
| Mol. Mass. | 435.8 |
|---|
| SMILES | Cl.NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
