| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-lysine 6-oxidase |
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| Ligand | BDBM50232678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1701351 (CHEMBL4052333) |
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| IC50 | 550±n/a nM |
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| Citation |  Rowbottom, MW; Bain, G; Calderon, I; Lasof, T; Lonergan, D; Lai, A; Huang, F; Darlington, J; Prodanovich, P; Santini, AM; King, CD; Goulet, L; Shannon, KE; Ma, GL; Nguyen, K; MacKenna, DA; Evans, JF; Hutchinson, JH Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem60:4403-4423 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-lysine 6-oxidase |
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| Name: | Protein-lysine 6-oxidase |
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| Synonyms: | LOX | LYOX_HUMAN | Lysyl oxidase | alpha-Glucosidase (alpha-Glu) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46954.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_306619 |
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| Residue: | 417 |
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| Sequence: | MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL
GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT
ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD
NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA
EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
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| BDBM50232678 |
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| n/a |
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| Name | BDBM50232678 |
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| Synonyms: | CHEBI:27413 | CHEMBL1618272 | US10717734, Compound BAPN | US11098045, Compound BAPN |
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| Type | Small organic molecule |
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| Emp. Form. | C3H6N2 |
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| Mol. Mass. | 70.0931 |
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| SMILES | NCCC#N |
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| Structure | 
|
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