Reaction Details |
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Target | Protein-lysine 6-oxidase |
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Ligand | BDBM50266785 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1701351 (CHEMBL4052333) |
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IC50 | 2800±n/a nM |
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Citation | Rowbottom, MW; Bain, G; Calderon, I; Lasof, T; Lonergan, D; Lai, A; Huang, F; Darlington, J; Prodanovich, P; Santini, AM; King, CD; Goulet, L; Shannon, KE; Ma, GL; Nguyen, K; MacKenna, DA; Evans, JF; Hutchinson, JH Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem60:4403-4423 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein-lysine 6-oxidase |
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Name: | Protein-lysine 6-oxidase |
Synonyms: | LOX | LYOX_HUMAN | Lysyl oxidase | alpha-Glucosidase (alpha-Glu) |
Type: | PROTEIN |
Mol. Mass.: | 46954.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_306619 |
Residue: | 417 |
Sequence: | MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL
GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT
ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD
NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA
EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
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BDBM50266785 |
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n/a |
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Name | BDBM50266785 |
Synonyms: | CHEMBL4066192 | US11358936, Compound 1-41 |
Type | Small organic molecule |
Emp. Form. | C22H21N3O2 |
Mol. Mass. | 359.421 |
SMILES | NCc1ccnc(Oc2cccc(c2)C(=O)N2CCc3ccccc3C2)c1 |
Structure |
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