| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Ligand | BDBM50267561 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1702993 (CHEMBL4054226) |
|---|
| IC50 | 454±n/a nM |
|---|
| Citation |  Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Synthesis of selective 11?-HSD1 inhibitors based on dammarane scaffold. Eur J Med Chem135:324-338 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32369.70 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | P50172 |
|---|
| Residue: | 292 |
|---|
| Sequence: | MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
|
|
|
|---|
| BDBM50267561 |
|---|
| n/a |
|---|
| Name | BDBM50267561 |
|---|
| Synonyms: | CHEMBL4084451 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H42O4 |
|---|
| Mol. Mass. | 418.6093 |
|---|
| SMILES | [H][C@@]12[C@H](CC[C@@]1(C)[C@]1(C)CC[C@@]3([H])C(C)(C)[C@H](CC[C@]3(C)[C@@]1([H])C[C@H]2O)OC(C)=O)C(C)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
