Reaction Details |
| Report a problem with these data |
Target | 11-beta-hydroxysteroid dehydrogenase 1 |
---|
Ligand | BDBM50267624 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1702996 (CHEMBL4054229) |
---|
IC50 | 729±n/a nM |
---|
Citation | Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Synthesis of selective 11?-HSD1 inhibitors based on dammarane scaffold. Eur J Med Chem135:324-338 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
11-beta-hydroxysteroid dehydrogenase 1 |
---|
Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
Type: | Enzyme |
Mol. Mass.: | 32409.16 |
Organism: | Homo sapiens (Human) |
Description: | P28845 |
Residue: | 292 |
Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
|
|
|
BDBM50267624 |
---|
n/a |
---|
Name | BDBM50267624 |
Synonyms: | CHEMBL4064979 |
Type | Small organic molecule |
Emp. Form. | C26H42O5 |
Mol. Mass. | 434.6087 |
SMILES | [H][C@@]12CC[C@]3(C)[C@]([H])(C[C@@H](O)C(=O)[C@@]3(C)CCC(=O)CC)[C@@]1(C)CC[C@H](OC(C)=O)C2(C)C |r| |
Structure |
|