| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM18512 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1703366 (CHEMBL4054599) |
|---|
| Ki | 470±n/a nM |
|---|
| Citation |  Tonelli, M; Naesens, L; Gazzarrini, S; Santucci, M; Cichero, E; Tasso, B; Moroni, A; Costi, MP; Loddo, R Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus. Eur J Med Chem135:467-478 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 21453.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human DHFR. |
|---|
| Residue: | 187 |
|---|
| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
|---|
| BDBM18512 |
|---|
| n/a |
|---|
| Name | BDBM18512 |
|---|
| Synonyms: | 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine | CHEMBL36 | Pyrimethamine (Pyr) | US11530198, Example Pyrimethamine | cid_4993 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H13ClN4 |
|---|
| Mol. Mass. | 248.711 |
|---|
| SMILES | CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
