| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 5 |
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| Ligand | BDBM50268010 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1704339 |
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| Kd | 88±n/a nM |
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| Citation |  Chang, Y; Lu, X; Shibu, MA; Dai, YB; Luo, J; Zhang, Y; Li, Y; Zhao, P; Zhang, Z; Xu, Y; Tu, ZC; Zhang, QW; Yun, CH; Huang, CY; Ding, K Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-? Motif Kinase (ZAK) Inhibitors. J Med Chem60:5927-5932 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 5 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
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| Synonyms: | MAP kinase kinase 5 | MAP2K5 | MAPK/ERK kinase 5 | MAPKK 5 | MEK5 | MKK5 | MP2K5_HUMAN | PRKMK5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50110.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1495740 |
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| Residue: | 448 |
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| Sequence: | MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
QFNDGNAAVVSMWVCRALEERRSQQGPP
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| BDBM50268010 |
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| n/a |
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| Name | BDBM50268010 |
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| Synonyms: | CHEMBL4098896 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H13F2N5O3S |
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| Mol. Mass. | 465.432 |
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| SMILES | COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(c2)C#N)c1F |
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| Structure | 
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