| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf |
|---|
| Ligand | BDBM50268010 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1704331 |
|---|
| IC50 | >1000±n/a nM |
|---|
| Citation |  Chang, Y; Lu, X; Shibu, MA; Dai, YB; Luo, J; Zhang, Y; Li, Y; Zhao, P; Zhang, Z; Xu, Y; Tu, ZC; Zhang, QW; Yun, CH; Huang, CY; Ding, K Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-? Motif Kinase (ZAK) Inhibitors. J Med Chem60:5927-5932 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase B-raf |
|---|
| Name: | Serine/threonine-protein kinase B-raf |
|---|
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 84446.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15056 |
|---|
| Residue: | 766 |
|---|
| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
|
|
|
|---|
| BDBM50268010 |
|---|
| n/a |
|---|
| Name | BDBM50268010 |
|---|
| Synonyms: | CHEMBL4098896 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H13F2N5O3S |
|---|
| Mol. Mass. | 465.432 |
|---|
| SMILES | COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(c2)C#N)c1F |
|---|
| Structure | 
|
|---|
Search and Browse
