| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase FRK |
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| Ligand | BDBM50268010 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1704335 (CHEMBL4055568) |
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| Kd | 22±n/a nM |
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| Citation |  Chang, Y; Lu, X; Shibu, MA; Dai, YB; Luo, J; Zhang, Y; Li, Y; Zhao, P; Zhang, Z; Xu, Y; Tu, ZC; Zhang, QW; Yun, CH; Huang, CY; Ding, K Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-? Motif Kinase (ZAK) Inhibitors. J Med Chem60:5927-5932 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase FRK |
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| Name: | Tyrosine-protein kinase FRK |
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| Synonyms: | FRK | FRK_HUMAN | FYN-related kinase | Nuclear tyrosine protein kinase RAK | PTK5 | RAK | SRC | Tyrosine Kinase FRK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 58254.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42685 |
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| Residue: | 505 |
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| Sequence: | MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED
LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA
IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR
RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL
GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED
PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV
LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG
ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF
ETLRWKLEDYFETDSSYSDANNFIR
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| BDBM50268010 |
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| n/a |
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| Name | BDBM50268010 |
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| Synonyms: | CHEMBL4098896 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H13F2N5O3S |
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| Mol. Mass. | 465.432 |
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| SMILES | COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(c2)C#N)c1F |
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| Structure | 
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