Reaction Details | |||
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Target | Tyrosine-protein kinase HCK | ||
Ligand | BDBM50268923 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1705445 (CHEMBL4056678) | ||
IC50 | 3.5±n/a nM | ||
Citation | Yuki, H; Kikuzato, K; Koda, Y; Mikuni, J; Tomabechi, Y; Kukimoto-Niino, M; Tanaka, A; Shirai, F; Shirouzu, M; Koyama, H; Honma, T Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen. Bioorg Med Chem25:4259-4264 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase HCK | |||
Name: | Tyrosine-protein kinase HCK | ||
Synonyms: | HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 59600.18 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08631 | ||
Residue: | 526 | ||
Sequence: |
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BDBM50268923 | |||
n/a | |||
Name | BDBM50268923 | ||
Synonyms: | CHEMBL4095434 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H36N6O2 | ||
Mol. Mass. | 512.6458 | ||
SMILES | Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CC[C@@H](CC1)N1CCN(CCO)CC1 |r,wU:23.26,wD:26.33,(17.06,-10.23,;17.07,-11.77,;15.74,-12.54,;15.74,-14.09,;17.07,-14.85,;18.41,-14.09,;19.89,-14.55,;20.8,-13.29,;19.88,-12.05,;20.35,-10.58,;21.85,-10.26,;22.32,-8.79,;21.28,-7.65,;21.74,-6.18,;23.24,-5.85,;24.28,-6.99,;25.79,-6.66,;26.25,-5.19,;25.21,-4.05,;23.71,-4.39,;19.76,-7.99,;19.31,-9.45,;18.4,-12.53,;20.38,-16.01,;21.88,-16.32,;22.36,-17.79,;21.33,-18.94,;19.82,-18.62,;19.35,-17.16,;21.81,-20.39,;20.78,-21.53,;21.25,-22.98,;22.75,-23.3,;23.22,-24.76,;22.2,-25.91,;22.67,-27.37,;23.78,-22.16,;23.31,-20.69,)| | ||
Structure |