Reaction Details |
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Target | Glycogen synthase kinase-3 beta |
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Ligand | BDBM50269429 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1706606 (CHEMBL4057839) |
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IC50 | 0.100000±n/a nM |
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Citation | Kohara, T; Nakayama, K; Watanabe, K; Kusaka, SI; Sakai, D; Tanaka, H; Fukunaga, K; Sunada, S; Nabeno, M; Saito, KI; Eguchi, JI; Mori, A; Tanaka, S; Bessho, T; Takiguchi-Hayashi, K; Horikawa, T Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3? inhibitors. Bioorg Med Chem Lett27:3733-3738 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 beta |
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Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
Type: | Enzyme |
Mol. Mass.: | 46756.38 |
Organism: | Homo sapiens (Human) |
Description: | P49841 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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BDBM50269429 |
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n/a |
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Name | BDBM50269429 |
Synonyms: | CHEMBL4084855 |
Type | Small organic molecule |
Emp. Form. | C21H24N6O2 |
Mol. Mass. | 392.4543 |
SMILES | COc1ccc(cc1)N1CCN([C@H](C)C1)c1nc(cc(=O)n1C)-c1ccncn1 |r| |
Structure |
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