| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 1A2 |
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| Ligand | BDBM50269460 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1706625 (CHEMBL4057858) |
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| IC50 | >50000±n/a nM |
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| Citation |  Usui, Y; Uehara, F; Hiki, S; Watanabe, K; Tanaka, H; Shouda, A; Yokoshima, S; Aritomo, K; Adachi, T; Fukunaga, K; Sunada, S; Nabeno, M; Saito, KI; Eguchi, JI; Yamagami, K; Asano, S; Tanaka, S; Yuki, S; Yoshii, N; Fujimura, M; Horikawa, T Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3? inhibitors. Bioorg Med Chem Lett27:3726-3732 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 1A2 |
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| Name: | Cytochrome P450 1A2 |
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| Synonyms: | CP1A2_HUMAN | CYP1A2 | CYPIA2 | Cholesterol 25-hydroxylase | Cytochrome P(3)450 | Cytochrome P450 1A | Cytochrome P450 1A2 (CYP1A2) | Cytochrome P450 4 | Cytochrome P450-P3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 58423.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05177 |
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| Residue: | 516 |
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| Sequence: | MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
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| BDBM50269460 |
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| n/a |
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| Name | BDBM50269460 |
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| Synonyms: | CHEMBL4061578 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24ClN5O2 |
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| Mol. Mass. | 413.901 |
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| SMILES | Cl.COc1cccc(c1)C1CN(CCN1)c1nc(cc(=O)n1C)-c1ccncc1 |
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| Structure | 
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