| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM17950 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1712840 (CHEMBL4122889) |
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| IC50 | 1.2±n/a nM |
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| Citation |  Tokuhara, H; Imaeda, Y; Fukase, Y; Iwanaga, K; Taya, N; Watanabe, K; Kanagawa, R; Matsuda, K; Kajimoto, Y; Kusumoto, K; Kondo, M; Snell, G; Behnke, CA; Kuroita, T Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile. Bioorg Med Chem26:3261-3286 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_MACMU |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44962.40 |
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| Organism: | Macaca mulatta |
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| Description: | ChEMBL_685579 |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLALGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNILSQGVLKEDVFSFYYNRDSENAQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIPMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAH
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| BDBM17950 |
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| n/a |
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| Name | BDBM17950 |
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| Synonyms: | (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide | ALISKIREN FUMARATE | Aliskiren | Aliskiren Hemifumarate | CHEMBL1639 | Rasilez | TEKTURNA |
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| Type | Small organic molecule |
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| Emp. Form. | C30H53N3O6 |
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| Mol. Mass. | 551.7583 |
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| SMILES | COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)ccc1OC |r| |
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| Structure | 
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