Reaction Details |
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Target | Cytoplasmic tyrosine-protein kinase BMX |
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Ligand | BDBM50276666 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1715921 |
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IC50 | 83±n/a nM |
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Citation | Wang, B; Deng, Y; Chen, Y; Yu, K; Wang, A; Liang, Q; Wang, W; Chen, C; Wu, H; Hu, C; Miao, W; Hur, W; Wang, W; Hu, Z; Weisberg, EL; Wang, J; Ren, T; Wang, Y; Gray, NS; Liu, Q; Liu, J Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors. Eur J Med Chem137:545-557 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytoplasmic tyrosine-protein kinase BMX |
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Name: | Cytoplasmic tyrosine-protein kinase BMX |
Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
Type: | Tyrosine-protein kinase |
Mol. Mass.: | 78030.42 |
Organism: | Homo sapiens (Human) |
Description: | P51813 |
Residue: | 675 |
Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
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BDBM50276666 |
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n/a |
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Name | BDBM50276666 |
Synonyms: | CHEMBL4166664 |
Type | Small organic molecule |
Emp. Form. | C25H19N5O2 |
Mol. Mass. | 421.4507 |
SMILES | Cc1ccc(cc1NC(=O)C=C)-n1c2c(ccc1=O)cnc1ccc(cc21)-n1cccn1 |
Structure |
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