| Reaction Details |
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 | Report a problem with these data |
| Target | Cytoplasmic tyrosine-protein kinase BMX |
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| Ligand | BDBM50245587 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1715921 |
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| IC50 | 6.7±n/a nM |
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| Citation |  Wang, B; Deng, Y; Chen, Y; Yu, K; Wang, A; Liang, Q; Wang, W; Chen, C; Wu, H; Hu, C; Miao, W; Hur, W; Wang, W; Hu, Z; Weisberg, EL; Wang, J; Ren, T; Wang, Y; Gray, NS; Liu, Q; Liu, J Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors. Eur J Med Chem137:545-557 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytoplasmic tyrosine-protein kinase BMX |
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| Name: | Cytoplasmic tyrosine-protein kinase BMX |
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| Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 78030.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51813 |
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| Residue: | 675 |
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| Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
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| BDBM50245587 |
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| n/a |
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| Name | BDBM50245587 |
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| Synonyms: | CHEMBL4077064 | US10000483, Compound II-4 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H21N5O2 |
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| Mol. Mass. | 447.4879 |
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| SMILES | Cn1cc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc5CCN(C(=O)C=C)c5c4)c3c2c1 |
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| Structure | 
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