| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Blk |
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| Ligand | BDBM50245587 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1715922 |
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| IC50 | 366±n/a nM |
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| Citation |  Wang, B; Deng, Y; Chen, Y; Yu, K; Wang, A; Liang, Q; Wang, W; Chen, C; Wu, H; Hu, C; Miao, W; Hur, W; Wang, W; Hu, Z; Weisberg, EL; Wang, J; Ren, T; Wang, Y; Gray, NS; Liu, Q; Liu, J Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors. Eur J Med Chem137:545-557 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Blk |
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| Name: | Tyrosine-protein kinase Blk |
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| Synonyms: | B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk |
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| Type: | Protein |
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| Mol. Mass.: | 57711.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51451 |
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| Residue: | 505 |
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| Sequence: | MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
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| BDBM50245587 |
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| n/a |
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| Name | BDBM50245587 |
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| Synonyms: | CHEMBL4077064 | US10000483, Compound II-4 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H21N5O2 |
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| Mol. Mass. | 447.4879 |
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| SMILES | Cn1cc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc5CCN(C(=O)C=C)c5c4)c3c2c1 |
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| Structure | 
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