| Reaction Details |
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 | Report a problem with these data |
| Target | Trypanothione reductase |
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| Ligand | BDBM50278487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1720239 (CHEMBL4135239) |
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| Ki | 2300±n/a nM |
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| Citation |  Uliassi, E; Fiorani, G; Krauth-Siegel, RL; Bergamini, C; Fato, R; Bianchini, G; Carlos Menéndez, J; Molina, MT; López-Montero, E; Falchi, F; Cavalli, A; Gul, S; Kuzikov, M; Ellinger, B; Witt, G; Moraes, CB; Freitas-Junior, LH; Borsari, C; Costi, MP; Bolognesi, ML Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity. Eur J Med Chem141:138-148 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Trypanothione reductase |
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| Name: | Trypanothione reductase |
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| Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR |
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| Type: | Homodimer; oxidoreductase |
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| Mol. Mass.: | 53868.26 |
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| Organism: | Trypanosoma cruzi |
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| Description: | n/a |
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| Residue: | 492 |
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| Sequence: | MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVP
KKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEG
LEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSN
EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELT
KQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNA
GVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHT
RVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHS
DGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVK
GEKMEKPSEASL
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| BDBM50278487 |
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| n/a |
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| Name | BDBM50278487 |
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| Synonyms: | CHEMBL3585376 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H21NO6 |
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| Mol. Mass. | 455.4587 |
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| SMILES | CN(C)CCOc1cc2ccc(OC3=CC(=O)c4cc5ccccc5cc4C3=O)cc2oc1=O |t:13| |
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| Structure | 
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