| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50157832 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1720244 (CHEMBL4135244) |
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| IC50 | 35000±n/a nM |
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| Citation |  Kankanala, J; Kirby, KA; Huber, AD; Casey, MC; Wilson, DJ; Sarafianos, SG; Wang, Z Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H. Eur J Med Chem141:149-161 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50157832 |
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| n/a |
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| Name | BDBM50157832 |
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| Synonyms: | 3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine-2,4-dione | CHEMBL361350 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H4N2O3S |
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| Mol. Mass. | 184.173 |
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| SMILES | On1c(=O)[nH]c2sccc2c1=O |
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| Structure | 
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