| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vitamin D3 receptor |
|---|
| Ligand | BDBM50281165 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1722372 (CHEMBL4137372) |
|---|
| IC50 | 1.8±n/a nM |
|---|
| Citation |  Yoshizawa, M; Itoh, T; Hori, T; Kato, A; Anami, Y; Yoshimoto, N; Yamamoto, K Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands. J Med Chem61:6339-6349 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vitamin D3 receptor |
|---|
| Name: | Vitamin D3 receptor |
|---|
| Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 48288.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11473 |
|---|
| Residue: | 427 |
|---|
| Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
|
|
|
|---|
| BDBM50281165 |
|---|
| n/a |
|---|
| Name | BDBM50281165 |
|---|
| Synonyms: | CHEMBL4176693 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H40O3 |
|---|
| Mol. Mass. | 412.6047 |
|---|
| SMILES | [H][C@@]1([#6]-[#6][C@@]2([H])\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1)[#6@H](-[#6])-[#6]-[#6]-[#6](=O)\[#6]=[#6]\[#6] |r| |
|---|
| Structure | 
|
|---|
Search and Browse
