| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-dependent RNA helicase DHX29 |
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| Ligand | BDBM65493 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1725525 (CHEMBL4140803) |
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| IC50 | >100000±n/a nM |
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| Citation |  Mizojiri, R; Nakata, D; Satoh, Y; Morishita, D; Shibata, S; Iwatani-Yoshihara, M; Kosugi, Y; Kosaka, M; Takeda, J; Sasaki, S; Takami, K; Fukuda, K; Kamaura, M; Sasaki, S; Arai, R; Cary, DR; Imaeda, Y Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1 ACS Med Chem Lett8:1077-1082 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-dependent RNA helicase DHX29 |
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| Name: | ATP-dependent RNA helicase DHX29 |
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| Synonyms: | DDX29 | DEAH box protein 29 | DHX29 | DHX29_HUMAN | Nucleic acid helicase DDXx |
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| Type: | Protein |
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| Mol. Mass.: | 155255.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q7Z478 |
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| Residue: | 1369 |
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| Sequence: | MGGKNKKHKAPAAAVVRAAVSASRAKSAEAGIAGEAQSKKPVSRPATAAAAAAGSREPRV
KQGPKIYSFNSTNDSSGPANLDKSILKVVINNKLEQRIIGVINEHKKQNNDKGMISGRLT
AKKLQDLYMALQAFSFKTKDIEDAMTNTLLYGGDLHSALDWLCLNLSDDALPEGFSQEFE
EQQPKSRPKFQSPQIQATISPPLQPKTKTYEEDPKSKPKKEEKNMEVNMKEWILRYAEQQ
NEEEKNENSKSLEEEEKFDPNERYLHLAAKLLDAKEQAATFKLEKNKQGQKEAQEKIRKF
QREMETLEDHPVFNPAMKISHQQNERKKPPVATEGESALNFNLFEKSAAATEEEKDKKKE
PHDVRNFDYTARSWTGKSPKQFLIDWVRKNLPKSPNPSFEKVPVGRYWKCRVRVIKSEDD
VLVVCPTILTEDGMQAQHLGATLALYRLVKGQSVHQLLPPTYRDVWLEWSDAEKKREELN
KMETNKPRDLFIAKLLNKLKQQQQQQQQHSENKRENSEDPEESWENLVSDEDFSALSLES
ANVEDLEPVRNLFRKLQSTPKYQKLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSG
KSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENGPGGRNSLCG
YQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKE
ILQKRSDLHLILMSATVDSEKFSTYFTHCPILRISGRSYPVEVFHLEDIIEETGFVLEKD
SEYCQKFLEEEEEVTINVTSKAGGIKKYQEYIPVQTGAHADLNPFYQKYSSRTQHAILYM
NPHKINLDLILELLAYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSNDRRFYSERYKV
IALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESS
QMSSLVETFVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCL
HIMKCNLGSPEDFLSKALDPPQLQVISNAMNLLRKIGACELNEPKLTPLGQHLAALPVNV
KIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLAKSALAMADSDHLTIYN
AYLGWKKARQEGGYRSEITYCRRNFLNRTSLLTLEDVKQELIKLVKAAGFSSSTTSTSWE
GNRASQTLSFQEIALLKAVLVAGLYDNVGKIIYTKSVDVTEKLACIVETAQGKAQVHPSS
VNRDLQTHGWLLYQEKIRYARVYLRETTLITPFPVLLFGGDIEVQHRERLLSIDGWIYFQ
APVKIAVIFKQLRVLIDSVLRKKLENPKMSLENDKILQIITELIKTENN
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| BDBM65493 |
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| n/a |
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| Name | BDBM65493 |
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| Synonyms: | eIF4A3 inhibitor, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H19Br2ClN4O2 |
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| Mol. Mass. | 602.705 |
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| SMILES | Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12 |r| |
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| Structure | 
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