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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Metabotropic glutamate receptor 7 | ||
| Ligand | BDBM50283489 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1725548 (CHEMBL4140826) | ||
| EC50 | 603±n/a nM | ||
| Citation |  Abe, M; Seto, M; Gogliotti, RG; Loch, MT; Bollinger, KA; Chang, S; Engelberg, EM; Luscombe, VB; Harp, JM; Bubser, M; Engers, DW; Jones, CK; Rodriguez, AL; Blobaum, AL; Conn, PJ; Niswender, CM; Lindsley, CW Discovery of VU6005649, a CNS Penetrant mGlu ACS Med Chem Lett8:1110-1115 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Metabotropic glutamate receptor 7 | |||
| Name: | Metabotropic glutamate receptor 7 | ||
| Synonyms: | GRM7_RAT | Gprc1g | Grm7 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 7 (mGlu7) | Mglur7 | mGlu7 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 102244.48 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | P35400 | ||
| Residue: | 915 | ||
| Sequence: |
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| BDBM50283489 | |||
| n/a | |||
| Name | BDBM50283489 | ||
| Synonyms: | CHEMBL4168668 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H12F5N3O | ||
| Mol. Mass. | 357.278 | ||
| SMILES | COc1cc(F)c(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1 |(75.94,-28.33,;76.96,-27.18,;76.48,-25.72,;74.97,-25.41,;74.49,-23.95,;72.98,-23.63,;75.51,-22.79,;75.03,-21.33,;75.93,-20.09,;77.47,-20.08,;75.01,-18.86,;73.56,-19.33,;72.23,-18.56,;70.9,-19.33,;70.9,-20.87,;69.56,-21.65,;72.23,-21.64,;73.57,-20.87,;72.23,-17.02,;73.56,-16.25,;70.89,-16.25,;72.21,-15.48,;77.01,-23.11,;78.04,-21.95,;77.51,-24.56,)| | ||
| Structure | 
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